WELCOME TO THE VLASHI LAB
Dr. Vlashi earned her PhD from the Department of Chemistry at Purdue University
with a focus on the characterization of in vivo trafficking and dynamic accumulation
of anti-cancer drugs targeted via high-affinity ligands to solid tumors. During her
post-doctoral training she expanded her expertise on cancer stem cells and
radiation oncology and made important discoveries that led to the development of
tools for identification, tracking and targeted elimination of cancer stem cells.
Employing the unique tools for cancer stem cell identification and isolation she
made the discovery that cancer stem cells reside in a metabolic state distinct from
the rest of the bulk tumor cell population.
Currently, the Vlashi Lab is building on the prior seminal discoveries on cancer stem
cell metabolism and is interested in investigating metabolic changes induced by
radiation therapy, how these changes dictate response to therapy, and how such
changes can be exploited with the goal of further enhancing benefit from radiation
therapy for cancer patients. Our ultimate goal is to develop novel agents against
breast cancer and glioblastoma, and their response to radiotherapy and
chemotherapy are prime targets for novel anticancer therapies.
In collaboration with other labs in the department Dr. Vlashi’s lab is also interested
in investigating radiation mitigators for the purpose of limiting radiation toxicity to
normal tissue during radiation therapy, with the ultimate goal of maximizing the
therapeutic index of this powerful anti-cancer treatment modality.